Professor Dai Zhifei, a member of the State Key Laboratory of Urban Water Resources and Water Environment, and the School of Science of Harbin Institute of Technology conducted years of in-depth and systematic research on environmental nanometer detection technology, nanotoxicology, and nanomedicine. Recently, a research group led by Prof. Dai Zhifei has made new progress in the research of therapeutic diagnostics and combinations. The research provides new ideas and methods for the development of advanced cancer diagnosis and treatment technologies.
The research group combined the high-contrast-enhanced imaging microcapsules with gold nanoshells for photothermotherapy to obtain a gold nanoshell-coated microcapsule. The microcapsules can well enhance the effect of ultrasound imaging, and can conveniently determine the size and position of the tumor, monitor the treatment process, and restore the process after treatment. On the other hand, gold nanoshells have strong absorption in the near-infrared region, which can convert the absorbed light energy into heat energy, increase the temperature in a localized area, effectively kill the malignant tumor cells, and treat the tumor with photothermal therapy. . The relevant research results were selected as hot papers and published in German Applied Chemistry (Impact Factor: 11.829). In March of this year, Wiley Publishing Co., Ltd. of Germany carried out “bright spot†reports and reviews. This news was later reproduced by some well-known professional websites in the United States and Germany in the field of technological innovation, nanometer and ultrasound, reflecting the laboratory’s Research in the field is already at the advanced level in the world. In April, the research results were reported as "research highlights" by Nature-Materials (influencing factor: 29.5).
After returning to China in 2005, Professor Dai Zhifei began to devote himself to the research of biosensors and nanomedicines for the detection of pollutants in the environment. Since 2007, Prof. Dai Zhifei has entered the State Key Laboratory of Urban Water Resources and Water Environment. With the support of the independent project of the State Key Laboratory of Urban Water Resources and Water Environment, he has carried out research on environmental nanosensors and designed and manufactured new types of nanomicro Foam ultrasound contrast agent can penetrate the tumor vascular endothelium and enter the tumor tissue to achieve tissue imaging. At the same time, a fluorescence/ultrasound dual-mode contrast agent based on quantum dot/microbubble complex is constructed, which makes medical imaging have higher sensitivity and With a higher resolution. On this basis, he led the research group to develop a series of new nanomaterials and conducted in-depth nanotoxicological studies. A novel composite liposome with high stability was screened and it is expected that a number of known nanoscale materials will be known. The highly toxic anti-cancer drugs are safely and effectively used in clinical treatment, and new nano-biosensors that are easy to carry, easy to use, and highly sensitive are developed, and have important application prospects in the fields of environmental monitoring, disease diagnosis, and food safety. Some of the relevant research results of this research are in Nanotoxicology (Influence Factor: 5.744), Chemical Communications (Impact Factor: 5.504), and Biosensors and Bioelectronics. (Impact Factor: 5.429), "The Journal of Materials Chemistry" (Impact Factor: 4.795) and other internationally renowned publications, including series of papers (including 2 cover papers), were reported twice by the famous British IOP Press as "research highlights." , And won the first prize of natural science in Heilongjiang Province in 2010.
The research group combined the high-contrast-enhanced imaging microcapsules with gold nanoshells for photothermotherapy to obtain a gold nanoshell-coated microcapsule. The microcapsules can well enhance the effect of ultrasound imaging, and can conveniently determine the size and position of the tumor, monitor the treatment process, and restore the process after treatment. On the other hand, gold nanoshells have strong absorption in the near-infrared region, which can convert the absorbed light energy into heat energy, increase the temperature in a localized area, effectively kill the malignant tumor cells, and treat the tumor with photothermal therapy. . The relevant research results were selected as hot papers and published in German Applied Chemistry (Impact Factor: 11.829). In March of this year, Wiley Publishing Co., Ltd. of Germany carried out “bright spot†reports and reviews. This news was later reproduced by some well-known professional websites in the United States and Germany in the field of technological innovation, nanometer and ultrasound, reflecting the laboratory’s Research in the field is already at the advanced level in the world. In April, the research results were reported as "research highlights" by Nature-Materials (influencing factor: 29.5).
After returning to China in 2005, Professor Dai Zhifei began to devote himself to the research of biosensors and nanomedicines for the detection of pollutants in the environment. Since 2007, Prof. Dai Zhifei has entered the State Key Laboratory of Urban Water Resources and Water Environment. With the support of the independent project of the State Key Laboratory of Urban Water Resources and Water Environment, he has carried out research on environmental nanosensors and designed and manufactured new types of nanomicro Foam ultrasound contrast agent can penetrate the tumor vascular endothelium and enter the tumor tissue to achieve tissue imaging. At the same time, a fluorescence/ultrasound dual-mode contrast agent based on quantum dot/microbubble complex is constructed, which makes medical imaging have higher sensitivity and With a higher resolution. On this basis, he led the research group to develop a series of new nanomaterials and conducted in-depth nanotoxicological studies. A novel composite liposome with high stability was screened and it is expected that a number of known nanoscale materials will be known. The highly toxic anti-cancer drugs are safely and effectively used in clinical treatment, and new nano-biosensors that are easy to carry, easy to use, and highly sensitive are developed, and have important application prospects in the fields of environmental monitoring, disease diagnosis, and food safety. Some of the relevant research results of this research are in Nanotoxicology (Influence Factor: 5.744), Chemical Communications (Impact Factor: 5.504), and Biosensors and Bioelectronics. (Impact Factor: 5.429), "The Journal of Materials Chemistry" (Impact Factor: 4.795) and other internationally renowned publications, including series of papers (including 2 cover papers), were reported twice by the famous British IOP Press as "research highlights." , And won the first prize of natural science in Heilongjiang Province in 2010.
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